Simulation-based inference (SBI) with machine learning is an increasingly important tool for solving inverse problems in science and engineering, including parameter inference and the inversion of detector effects. We provide an overview of the Bayesian and frequentist statistical frameworks, describe how machine-learning-based SBI methods, such as neural posterior estimation and neural likelihood estimation, can be used for parameter estimation within these frameworks, and show that the same methods can also be applied to Empirical Bayes or unfolding tasks. We also discuss how to validate inference results and the limitations of SBI with machine learning.
Low-thrust trajectory optimization is a core technology in deep-space mission design. Indirect methods based on Pontryagin's Minimum Principle (PMP) offer rigorous optimality guarantees, yet their practical application faces three bottlenecks: (1) transversality conditions must be derived case by case for each constraint type; (2) different dynamics models require repeated code rewrites; and (3) shooting equations are highly sensitive to initial guesses. This paper presents HELIOS (Heuristic Engine for Low-thrust Interplanetary Optimization System), a trajectory optimization agent built around a large language model (LLM). Given a physical problem described in natural language, the system autonomously performs PMP symbolic derivation, SymPy verification, C++ shooting-code generation, and numerical solution without human intervention. Key innovations include: (1) a constraint-adaptive derivation framework that unifies arbitrary constraints into psi(x,p)=0 form and automatically generates stationarity conditions for free parameters (e.g., gravity-assist turning angle); (2) dynamics-adaptive four-module code generation supporting non-standard dynamics (solar sail, J2 perturbation) without modifying the underlying template; and (3) a general derivation rule set covering critical error-prone points in PMP derivation. Experiments on 11 progressive test scenarios show that HELIOS correctly derives and solves problems from simple rendezvous (8 variables) to multi-leg stay transfers (48 variables), gravity-assist trajectories (17 variables), and solar-sail minimum-time transfers (8 variables). The best compilation success rate reaches 100% (11/11). A multi-model comparison (8 open-source LLM backends, total scores 250-905) verifies the model-agnostic architecture and reveals a positive correlation between model scale and derivation capability.